Cissus quadrangularis is an ancient medicinal plant native to the hotter parts of Ceylon and India traditionally used for it's healing properties. Modern research has shown that Cissus acts as a glucocorticoid antagonist and may possesses anabolic and/or androgenic properties. It has been used to safely repair bones, tendons an ligaments. Scientific trials have shown that Cissus has led to an increase in healing time of up to 55% faster than that of a placebo.

In addition, Cissus has been show to significantly lower cortisol, be a potent anti-catabolic, an effective painkiller and an anti inflammatory Despite all these benefits, Cissus has been show to be completely safe even at mega doses.